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. 2017 Sep 22;12(9):e0185236. doi: 10.1371/journal.pone.0185236

Fig 2. Deletion of SIRT1 in osteoclasts or osteoblasts results in a low bone mass phenotype.

Fig 2

(A) Osteoclast tissue specific SIRT1 knockout mice (OcKO) show excision of SIRT1 in osteoclasts, but not liver, as indicated by a smaller PCR product obtained with primers flanking SIRT1 catalytic exon 4 (T1Δ4). OcKOs show decreased bone mass at both 1 month and 4 months of age. (B) Osteoblast tissue specific SIRT1 knockout mice (ObKO) mice show excision of SIRT1 in calvaria, but not liver. ObKOs show decreased bone mass only at 4 months of age. (n ≥ 5 for each group; * p < .05; ** p < .01).