Fig 2. Analysis of Δ_AIC values.

(A) Differences in the Akaike information criterion values between the causal and colliding models (Δ_AIC) in triplets best supported by either model. On average, the colliding models have higher Δ_AIC values. This indicates that we are more likely to identify genes whose expression is in some way regulated by CRP. (B) Scatter plot of Δ_AIC values against the CRP-expression association p-values with a linear trend and 95% confidence interval. Despite a small positive trend, we can observe that higher correlation does not necessarily translate to more evidence of a causal effect.