Table 1.

Time-dependent effect of different inhibitors on cytokine production by KCs

Groups	TNF-α, pg/mL	IL-1β, pg/mL	IL-6, pg/mL
Control	2.20±0.20	5.03±0.91	7.73±1.23
NY 18 h	1.87±0.15*	4.48±0.78	7.51±1.49
NY 6 h	1.87±0.25	4.97±0.97	6.94±0.89
NY 2 h	1.96±0.28	4.27±0.94	6.69±1.39
AMR 18 h	2.10±0.27	4.93±0.73	7.87±0.87
AMR 6 h	1.68±0.56	4.48±1.35	7.25±1.18
AMR 2 h	1.92±0.29	4.59±1.16	6.94±1.02
CPZ 18 h	1.82±0.11**	3.80±1.02	6.43±1.44
CPZ 6 h	2.13±0.32	4.55±2.19	6.14±0.33*
CPZ 2 h	1.92±0.26	4.28±0.29	7.45±0.56
Col 18 h	1.68±0.36*	3.88±0.76	6.53±0.95
Col 6 h	1.68±0.30*	4.27±1.39	6.74±1.59
Col 2 h	1.74±0.21*	4.43±0.99	6.21±1.23
PDTC 18 h	1.85±0.25	3.62±1.10	5.82±0.09*
PDTC 6 h	1.73±0.23*	4.02±0.48	7.06±1.59
PDTC 2 h	1.88±0.21	4.38±1.10	5.20±0.80**

Notes: Values are presented as mean ± SD (n=5).

^*P<0.05;

^**P<0.01 vs control.

Abbreviations: AMR, amiloride; Col, colchicine; CPZ, chlorpromazine; IL, interleukin; KCs, Kupffer cells; NY, nystatin; PDTC, pyrrolidine dithiocarbamate; TNF-α, tumor necrosis factor.