Table 3.
Cox’s proportional hazard regression analysis of the prognostic value of clinical and immunohistochemical variables in 53 women with uterine leiomyosarcomas
| Prognostic factor | Disease free survival (DFS)
|
Overall survival (OS)
|
||
|---|---|---|---|---|
| HR (CI) | p-value | HR (CI) | p-value | |
| Age | 0.973 (0.921–1.029) | 0.348 | 0.964 (0.910–1.020) | 0.206 |
| Stage 3+ | 9.024 (1.196–81.968) | <0.001# | 14.153 (6.061–33.049) | <0.001# |
| Grade 3 | 2.226 (1.064–4.656) | 0.031# | 2.396 (1.148–4.999) | 0.019# |
| MI >50 | 4.674 (2.184–10.014) | <0.001# | 18.601 (5.703–60.670) | <0.001# |
| Negative DFF40 staining | 3.254 (3.254–6.459) | 0.007# | 6.315 (2.712–14.704) | <0.001# |
| Negative DFF45 staining | 1.359 (0.715–2.583) | 0.349 | 1.587 (0.829–3.044) | 0.164 |
| Negative Bcl-2 staining | 3.893 (1.940–7.812) | <0.001# | 11.476 (4.454–29.564) | <0.001# |
Note:
#
p, significant p value.
Abbreviations: DFF40, DNA fragmentation factor 40; DFF45, DNA fragmentation factor 45; Bcl-2, B-cell lymphoma 2 protein; CI, confidence intervals; HR, hazard ratio; MI, mitotic index.