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. 2017 Sep 18;10:2253–2262. doi: 10.2147/JPR.S130654

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© 2017 Shao et al. This work is published and licensed by Dove Medical Press Limited

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Effects of RG108 on the expression of DNMT3a and MOR in the spinal cord.

Notes: (A) Western blot shows that intrathecal RG108 treatment inhibits DNMT3a expression at the spinal level in both sham-operated and nerve-injured mice at day 7 after surgery (n=6/group). (B) MOR protein in the spinal cord was upregulated by intrathecal RG108 treatment at day 7 following CCI, while no MOR protein increase was observed in RG108-treated sham mice (n=6/group). β-Actin was used as an internal control. Data are presented as mean ± SEM. One-way ANOVA followed by Bonferroni’s test. *p<0.05 or **p<0.01 versus before operation; ^#p<0.05 or ^##p<0.01 compared to the corresponding vehicle-treated group.

Abbreviations: MOR, mu opioid receptor; DNMT3a, DNA methyltransferase3a; CCI, chronic constriction injury; ANOVA, analysis of variance; SEM, standard error of the mean.