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. Author manuscript; available in PMC: 2017 Sep 22.
Published in final edited form as: Mass Spectrom Rev. 2014 Nov 5;35(5):601–619. doi: 10.1002/mas.21447

FIGURE 9.

FIGURE 9

Chemical proteomic method for the characterizations of protein prenylation. A: A scheme of protein prenylation by formation of a thioether linkage between the prenyl group and one or two C-terminal cysteines of the protein substrate. Prenylation reaction can be catalyzed by the CAAX prenyltransferases FTase and GGTase-I or CXC prenyltransferase RabGGTase. B: The chemical structure of FPP-azide and BGPP in comparison with the natural prenylation substrates FPP and GGPP. Modified from Nguyen et al. (2009).