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. Author manuscript; available in PMC: 2018 Oct 11.
Published in final edited form as: Neuroscience. 2017 Aug 12;361:129–143. doi: 10.1016/j.neuroscience.2017.08.013

Fig. 2. AIE leads to blunted acetylcholine (ACh) efflux in the prefrontal cortex (PFC) during spontaneous alternation, but does not impair alternation behavior.

Fig. 2

(A) Average percent alternation scores by AIE treatment. There was no effect of AIE on alternation behavior. (B) Arm entries during spontaneous alternation. There was no significant difference in activity between AIE and control groups. (C) Hippocampal ACh efflux before (baseline), during (maze) and after spontaneous alternation behavior (post maze). There was a main effect of phase, wherein ACh efflux significantly increased during maze behavior compared to baseline and post maze levels (p<0.05). AIE did not affect ACh efflux in the hippocampus. (D) Prefrontal cortical ACh efflux measured during baseline, maze behavior and post maze. There was a main effect of phase, with ACh levels increasing during maze behavior (p<0.05). There was also a significant interaction between AIE treatment and phase: AIE blunted the rise in ACh efflux during maze behavior in the PFC (T; p<0.05).