Fig. 5.

Relationship between inhibition of dehydrogenase activity in cells (IC50) and hydrophobicity of the drugs. IC50s on cellular dehydrogenase activity were determined for each drug using WST-1, tabulated in Table 2. Calculated hydrophobicity for each compound was used as for Fig. 3a to depict the relationship between log IC50 and clogD. Plot of phenformin (triangle) and (left to right) DG4, DG5, DG6, DG7, DG8 and DG10 (squares). A lower log IC50 indicates a more potent compound. Effects of each dose were measured at least six times, each from a separate well of cells.