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(A) and (B) Knockdown of SAV1 repressed the apoptosis of PANC-1 cells. (C) and (D) Overexpression of SAV1 promoted the apoptosis of AsPC-1 cells. (E) and (F) AsPC-1cells treated with the demethylating agent 5-azaC resulted in restored expression of SAV1. Furthermore, restored SAV1 promoted the apoptosis of AsPC-1 cells.
