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. 2017 May 19;8(38):62962–62975. doi: 10.18632/oncotarget.18002

Figure 9. PTC-209 enhances radiosensitivity of DIPG cells to DNA damage.

Figure 9

(A) Immunoblot of CHK1 levels in DIPG patient tumor (T) and matched normal (N) tissue. (B) Immunoblot of CHK1 levels in DIPG cell lines treated for 3 days with 5 μM PTC-209. (C) Experimental design of the PTC-209 and bleocin combination treatment. (D) Cell growth measured by WST-1 assay, and represented as percent (%) of cell growth at 24 hrs compared to 0 h after addition of Bleocin. Error bars represent standard deviation from independent experiments each run in triplicates. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. Δ, P < 0.05; ΔΔ, P < 0.01; ΔΔΔ, P < 0.001; ΔΔΔΔ, P < 0.0001. $, P < 0.05; $$, P < 0.01; $$$, P < 0.001; $$$$, P < 0.0001. * denotes comparison with DMSO, Δ denotes comparison with PTC-209 and $ denotes comparison with Bleocin.