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. 2017 Jun 27;8(38):63073–63083. doi: 10.18632/oncotarget.18634

Table 3. Univariate analysis for hospital short-term mortality of patients with acute myocarditis.

Clinical variables HRs 95% CI p Value
Age (year) 1.031 1.01 to 1.05 0.001
Males, n (%) 0.921 0.51 to 1.67 0.785
CK (U/L) 1.415 1.21 to 1.66 <0.001
LDH (U/L) 1.721 1.40 to 2.12 <0.001
ALT (U/L) 1.373 1.21 to 1.55 <0.001
AST (U/L) 1.500 1.32 to 1.71 <0.001
cTnI (ng/ml) 1.613 1.38 to 1.88 <0.001
NT-proBNP (pg/ml) 1.795 1.47 to 2.20 <0.001
CRP (mg/L) 1.851 1.51 to 2.27 <0.001
ESR (mm/H) 1.039 0.83 to 1.30 0.739
D-dimer (ug/mL) 1.126 1.07 to 1.19 <0.001
HCO3 (mmol/L) 1.279 1.19 to 1.38 <0.001
HCT (%) 1.068 1.02 to 1.12 0.009
WBC (*109/L) 1.103 1.05 to 1.16 <0.001
PLT (*109/L) 1.005 1.00 to 1.01 0.008
Serum creatinine (mg/dL) 3.994 2.20 to 7.26 <0.001
BUN (mmol/L) 1.144 1.09 to 1.20 <0.001
eGFR (ml/min/1.73m2) 1.021 1.01 to 1.03 <0.001
UA (umol/L) 1.003 1.00 to 1.00 <0.001
Admission SBP (mmHg) 1.044 1.03 to 1.06 <0.001
Admission DBP (mmHg) 1.054 1.03 to 1.08 <0.001
Hypotension, n (%) 4.855 2.61 to 9.03 <0.001
NYHA (III or IV), n (%) 9.400 4.68 to 18.88 <0.001
LVEF (%) 1.059 1.04 to 1.08 <0.001
Arrhythmia, n (%) 2.437 1.30 to 4.59 0.006
Temporary pacing, n (%) 0.701 0.20 to 2.46 0.579
Inotropic agents, n (%) 0.060 0.03 to 0.13 <0.001
IABP support, n (%) 0.245 0.11 to 0.55 0.001
SOFA score 1.903 1.63 to 2.22 <0.001
APACHE IV score 1.145 1.11 to 1.18 <0.001
SAPS II score 1.219 1.16 to 1.28 <0.001

CK, Creatine Kinase; LDH, Lactate Dehydrogenase; cTnI, cardiac troponin I; NT-proBNP, N-terminal B-type natriuretic peptide; CRP, C reactive protein; ESR, erythrocyte sedimentation rate; HCT, Red blood cell specific volume; WBC, white blood cell; PLT, platelet count; BUN, blood urea nitrogen; eGFR, Estimated glomerular filtration rate; UA, uric acid; SBP, systolic blood pressure; DBP, diastolic blood pressure; Hypotension, MAP (mean arterial pressure) <70 mmHg; LVEF, left ventricular ejection fraction; IABP, intra-aortic balloon pump; SOFA, Sequential Organ Failure Assessment; APACHE IV, Acute Physiology and Chronic Health Evaluation IV; SAPS II, second Simplifed Acute Physiology Score.