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. 2017 Jun 27;8(38):63121–63131. doi: 10.18632/oncotarget.18670

Figure 1. H3F3A molecular screening.

Figure 1

(A) Haematoxylin and eosin staining of conventional GCT biopsy used for DNA extraction and carrying p.Gly34Trp somatic mutation in H3F3A. (B) The DNA sequence of a segment flanking p.Gly34Trp somatic mutation in H3F3A from a conventional GCT patient. (C) Output of the H3F3A targeted sequencing in our cohort of 44 conventional GCT patients. (D) Allele specific sequencing of cloned DNA fragment containing p.Gly34Leu somatic mutation in H3F3A resulting from a substitution of two adjacent nucleotides.