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. 2017 Jun 27;8(38):63121–63131. doi: 10.18632/oncotarget.18670

Figure 3. Histological comparison of the GCT markers between conventional and pagetic GCT.

Figure 3

FGFR2IIIc immunoreactivity was detected in mesenchymal GCT cells interspersed among the negative OCL-like giant cells, while it was absent in GCT/PDB tumor tissue. TWIST1 immunostaining was observed in the nuclei of mesenchymal stromal cells and in their cytoplasm (moderate signal) in both tumors. TNC detection showed reticulate-fibrillar pattern in GCT and GCT/PDB tumor tissues mainly referred to the spindle mononuclear cells. EGFR localised in cell membranes of the spindle shaped mononuclear cells. RANKL showed similar distribution in mesenchymal stromal cells in both tumors.