Table 2. Univariate and multivariate analyses in ESCC patients.
| Univariate analysis | P-value | Multivariate analysis | P-value | |
|---|---|---|---|---|
| HR (95% CI) | HR (95% CI) | |||
| Age (years) | 0.967 | - | - | |
| >60 vs. ≤60 | 1.007 (0.737-1.376) | |||
| Gender | 0.138 | - | - | |
| male vs. female | 1.425 (0.892-2.274) | |||
| Tumor length (cm) | 0.292 | - | - | |
| >5.0 vs. ≤5.0 | 1.204 (0.852-1.700) | |||
| Tumor location | 0.379 | - | - | |
| lower vs. upper/middle | 1.120 (0.870-1.442) | |||
| Vessel invasion | 0.002 | 0.742 | ||
| positive vs. negative | 1.752 (1.225-2.504) | 1.068 (0.722-1.579) | ||
| Perineural invasion | 0.018 | 0.957 | ||
| positive vs. negative | 1.553 (1.079-2.233) | 1.011 (0.682-1.499) | ||
| Differentiation | 0.060 | - | - | |
| poor vs. well/moderate | 1.278 (0.989-1.650) | |||
| T stage | <0.001 | 0.045 | ||
| T3-4 vs. T1-2 | 2.193 (1.559-3.087) | 1.472 (1.009-2.149) | ||
| N stage | <0.001 | <0.001 | ||
| N1-3 vs. N0 | 2.671 (1.957-3.644) | 1.975 (1.385-2.816) | ||
| CRP (mg/L) | <0.001 | 0.466 | ||
| >10.0 vs. ≤10.0 | 2.152 (1.563-2.963) | 1.193 (0.743-1.914) | ||
| SCC (ng/ml) | 0.016 | 0.926 | ||
| >1.50 vs. ≤1.50 | 1.492 (1.077-2.066) | 0.981 (0.660-1.458) | ||
| CCS | <0.001 | 0.004 | ||
| >15.8 vs. ≤15.8 | 2.853 (2.090-3.896) | 2.092 (1.272-3.441) |
ESCC=esophageal squamous cell carcinoma; CRP= c-reactive protein; SCC= squamous cell carcinoma antigen; CCS=combination of CRP and SCC; HR=hazard ratio; CI=confidence interval
Statistical methods: Univariate and multivariate analyses.