Table 4. Spearman correlation between DFX Ctrough, ductopenia ratio, and MTIC versus clinical variables.

Patients, n = 42	DFX Ctrough,μg/mL		Ductopenia,ratio†		MTIC,μmol/g
	r	p	r	p	r	p
DFX treatment duration (days)	−0.6932	<0.0001	0.4299	0.0044	0.6954	<0.0001
DFX Ctrough (μg/mL)	-	-	−0.4301	0.0044	−0.9159	<0.0001
Ferritin (ng/mL)	−0.1787	0.2573	−0.2334	0.1369	0.2762	0.0766
Organs with IO (n)	0.0900	0.5706	−0.4059	0.0076	0.9264	<0.0001
MTIC (μmol/g)	−0.9159	<0.0001	0.4649	0.0019	-	-
Neutrophil (count/μL)	−0.4203	0.0056	0.3451	0.0252	0.4345	0.0040
Hemoglobin (g/dL)	−0.3031	0.0510	0.2801	0.0723	0.3216	0.0378
Platelets (×103/μL)	−0.3680	0.0165	0.2340	0.1357	0.3296	0.0330
AST (U/L)	0.4412	0.0034	−0.4725	0.0016	−0.4168	0.0060
ALT (U/L)	0.4005	0.0086	−0.3660	0.0171	−0.3869	0.0114
Blood total bilirubin (mg/dL)	0.5960	<0.0001	−0.3532	0.0217	−0.3768	0.0139
Blood direct bilirubin (mg/dL)	0.7433	<0.0001	−0.4707	0.0016	−0.5231	0.0004
Clearance creatinine (mL/min/m2)	−0.7196	<0.0001	0.5223	0.0004	0.6729	<0.0001

DFX, deferasirox; MTIC, mean tissue iron concentration; IO, iron overload; AST, aspartate aminotransferase; ALT, alanine aminotransferase.

†Ductopenia is expressed as the ratio of the number of interlobular bile ducts to number of portal tracts.