Table 6. Inhibition of compounds 13 and 14 on the growth of cancer cells and normal cells.
| compound | EC50 (μM) | |||
|---|---|---|---|---|
| MDA-MB-231b | MCF-7c | A549d | HEK293e | |
| 13 | 89.33±1.23 | 79.43±2.72 | >100a | 56.96±1.12 |
| 14 | 10.02±1.66 | 37.36±2.20 | 36.24±1.76 | 19.95±0.19 |
| SAHA | 2.874±0.84 | 8.124±4.98 | 19.31±1.26 | 2.482±1.13 |
| BIX-01294 | 2.155±0.88 | 8.103±1.99 | 21.74±2.73 | 2.048±0.98 |
a>100 in the cases where the IC50 did not reach at the highest tested concentration (100 μM).
bMDA-MB-231: breast cancer cell line; cMCF-7: breast cancer cell line; dA549: human lung cancer cell line; eHEK293 normal cell line; SAHA and BIX-01294 were used as the positive controls; Cells were exposed to the different inhibitors with various concentrations for 72h. Inhibition of cell growth by the listed compounds was determined by using CCK-8 kit. Data shown as mean ± SD of triplicates.