Table 1. Pharmacokinetic parameters of Bufalin and Bufalin-BSA-NP at doses of 0.15, 0.3 and 0.6 mg/kg.
| Pharmacokinetic parameters | 0.6 (mg/kg) | 0.3 (mg/kg) | 0.15 (mg/kg) | |||
|---|---|---|---|---|---|---|
| Bufalin | Bufalin-BSA-NP | Bufalin | Bufalin-BSA-NP | Bufalin | Bufalin-BSA-NP | |
| Cmax (ng/mL) | 2430.5 | 2186.2 | 682.3 | 599.9 | 515.6 | 474.3 |
| t1/2 (min) | 43.2 | 127.2 | 39 | 93 | 34.8 | 75.6 |
| MRT (min) | 19.2 | 68.4 | 24.6 | 88.8 | 24 | 51 |
| AUC0-8 (ng h/mL) | 299.7 | 380.8 | 126.6 | 229.6 | 77.6 | 92.5 |
| AUC0-∞ (ng h/mL) | 302.6 | 389.7 | 128.22 | 233.48 | 78.53 | 94.98 |
| Vd (L/kg) | 0.64 | 1.76 | 0.95 | 1.90 | 0.76 | 1.34 |
| CL (L/h kg) | 2.00 | 1.54 | 2.34 | 1.29 | 1.93 | 1.58 |
Bufalin-BSA-NP: Bufalin-loaded bovine serum albumin nanoparticle; t1/2: half-life of plasma; Cmax: maximum concentration; MRT: mean residence time; AUC: area under the curve; Vd: aparent volume of distribution; CL: clearance.