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. 2017 Jun 28;8(38):63484–63505. doi: 10.18632/oncotarget.18833

Table 3. Upstream regulators that positively regulate EPC gene expression as determined by Ingenuity Pathway Analysis.

Molecule type Upstream regulator Biological function No. of target genes P-value Z-score
Transcription Regulator MYC Cell proliferation, cell cycle regulation 457 2.32E-83 8.884
TP53 Cell cycle regulation 563 2.23E-82 4.559
HNF4A Glucose homeostasis, lipid homeostasis 728 1.51E-81 2.167
MYCN Cell proliferation 165 2.67E-60 2.925
XBP1 Cellular response to nutrient, cell growth 124 5.36E-40 9.837
NFE2L2 Cellular response to stress 166 1.56E-26 11.009
HIF1A Cellular response to hypoxia 147 3.55E-20 8.085
HTT Regulation of mitochondrial function 232 6.71E-20 4.924
E2F1 Cell cycle regulation 168 9.48E-20 4.241
FOS Cellular response to stimulus 187 1.12E-18 2.507
Nuclear Receptor ESR1 Ovarian follicle growth 438 9.49E-41 5.358
PGR Cellular response to gonadotropin 110 1.53E-16 6.862
PPARG Lipid metabolism, glucose homeostasis 139 9.64E-10 3.756
PPARA Glucose metabolism, fatty acid metabolism 116 9.18E-06 4.608
AR Cell growth and proliferation 116 2.05E-05 6.679
ESRRA Cell proliferation 53 1.86E-04 5.735
ESRRG Cell proliferation 14 7.26E-03 3.121
Growth Factor TGFB1 Cell growth and proliferation, migration 550 1.54E-49 10.924
HGF Cell proliferation migration 180 8.4E-21 8.682
ANGPT2 Cell differentiation, germ cell development 85 2.84E-16 6.092
VEGFA Cell migration, angiogenesis 102 2.05E-14 7.275
EGF Potent mitogenic factor 159 7.61E-13 8.927
TGFB3 Cell growth and proliferation 48 9.23E-11 5.633
AGT Extracellular matrix organization 136 5.25E-10 7.643
IGF1 Cellular response to insulin and glucose 120 4.03E-08 6.814
FGF2 Cell division and proliferation 106 2.65E-07 6.851
KITLG Germ cell development, ovarian follicle development 71 4.97E-06 5.675