Table 4. Cox model with hazard ratios and 95% confidence intervals of sub-division cancer associated with candida infection stratified by age.
| Variable (ICD-9-CM) | Age≤49 years | Age ≥50 years | ||
|---|---|---|---|---|
| Candida infection | Candida infection | |||
| No (N=27786) | Yes (N=27771) | No (N=7043) | Yes (N=7058) | |
| Adjusted HR† (95%CIn) | Adjusted HR† (95%CIn) | |||
| All cancers | 1(Reference) | 0.96(0.85, 1.09) | 1(Reference) | 1.27(1.12, 1.43)*** |
| Hematologic malignancy | 1(Reference) | 1.78(1.04, 3.04)* | 1(Reference) | 2.41(1.45, 4.02)*** |
| Myeloid leukemia | 1(Reference) | 2.10(0.87, 5.08) | 1(Reference) | 3.24(1.05, 9.96)* |
| Non-Hodgkin'slymphoma | 1(Reference) | 1.61(0.72, 3.61) | 1(Reference) | 2.12(1.09, 4.09)* |
| Head and neck cancer | 1(Reference) | 1.58(0.93, 2.68) | 1(Reference) | 3.54(2.06, 6.10)*** |
| Lip | 1(Reference) | - | 1(Reference) | 9.65(1.22, 76.3)* |
| Oral cavity | 1(Reference) | 2.12(1.04, 4.34)* | 1(Reference) | 4.20(2.01, 8.75)*** |
| Pancreas | 1(Reference) | - | 1(Reference) | 0.72(0.38, 1.37) |
| Skin | 1(Reference) | 1.32(0.22, 8.13) | 1(Reference) | 2.35(0.97, 5.65) |
| Thyroid | 1(Reference) | 1.25(0.84, 1.87) | 1(Reference) | 2.93(1.07, 8.03)* |
Adjusted HR†: multivariable analysis including age, sex, monthly-income, urbanization level, occupation, and comorbidity of chronic obstructive pulmonary disease, connective tissue disease, chronic renal failure, chronic liver failure, inflammatory bowel disease, diabetes, hypertension, hyperlipidemia, HIV infection, coronary artery disease, and drug dependence.
*p<0.05, ***p<0.001.