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. 2017 Jun 29;8(38):63620–63634. doi: 10.18632/oncotarget.18872

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Copyright: © 2017 Schachtschneider et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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(A) Trichrome stained Oncopig liver 8 weeks following cirrhosis induction shows irregular and morphologically effaced hepatic lobules circumferentially surrounded by thick fibrous septa (arrowheads) consistent with stage 4 liver fibrosis (cirrhosis; scale bar 600 μm). (B) Trichrome stain of normal Oncopig control liver shows morphologically non-expanded portal tracts maintaining their usual hexagonal distribution, without cetrilobular venular and sinusoidal thickening (scale bar 600 μm).