Figure 4. The median dose-effect method of Chau and Talalay and Compusyn software were used to examine the interaction between gemcitabine and entinostat in each cell line.

(A) Summary table of all the combination index (CI) values obtained from the analysis and their interpretation. CI values < 1 indicates synergy, CI=1 indicates additive and CI values > 1 indicates antagonism between the two drugs. (B) The CI values are expressed graphically as normalised isobolograms.