Table 1. Summary of the protein profiles with high expression levels detected by shotgun proteomic assays in ovarian carcinomas.
| Accession number | Protein | Gene symbol | OCCCa | OEmCa | OSeCa | OMuCa | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Spectral counts | Positive | Spectral counts | Positive | Spectral counts | Positive | Spectral counts | Positive | |||||||||||||||
| C1 | C2 | C3 | C4 | cases | E1 | E2 | E3 | E4 | cases | S1 | S2 | S3 | S4 | cases | M1 | M2 | M3 | M4 | cases | |||
| P84085 | ADP-ribosylation factor 5 | ARF5 | 3 | 3 | 3 | 2 | 4 | 1 | 1 | 1 | 2 | 1 | 3 | 1 | 1 | 2 | 2 | 2 | 1 | 2 | 1 | 2 |
| P19801 | Amiloride-sensitive amine oxidase [copper-containing] | ABP1 | 11 | 18 | 15 | 15 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 5 | 15 | 3 |
| P06727 | Apolipoprotein A-IV | APOA4 | 2 | 2 | 10 | 3 | 4 | 13 | 0 | 0 | 4 | 2 | 2 | 5 | 0 | 3 | 3 | 3 | 0 | 1 | 11 | 2 |
| E9PK09 | Bcl-2-associated transcription factor 1 (Fragment) | BCLAF1 | 3 | 5 | 3 | 4 | 4 | 1 | 4 | 2 | 2 | 3 | 0 | 2 | 4 | 2 | 3 | 2 | 1 | 1 | 1 | 1 |
| P15291 | Beta-1, 4-galactosyl transferase 1 | B4GALT1 | 4 | 2 | 4 | 4 | 4 | 1 | 2 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 4 | 1 | 1 | 1 |
| Q9P2M7 | Cingulin | CGN | 4 | 7 | 2 | 2 | 4 | 1 | 2 | 2 | 2 | 3 | 2 | 2 | 3 | 2 | 4 | 0 | 5 | 3 | 2 | 3 |
| Q01955 | Collagen alpha-3(IV) chain | COL4A3 | 2 | 2 | 3 | 4 | 4 | 2 | 2 | 2 | 1 | 3 | 2 | 2 | 1 | 2 | 3 | 1 | 1 | 2 | 2 | 2 |
| F6RFD5 | Destrin | DSTN | 2 | 4 | 2 | 2 | 4 | 1 | 1 | 3 | 2 | 2 | 3 | 3 | 1 | 3 | 3 | 1 | 2 | 2 | 3 | 3 |
| P53634 | Dipeptidyl peptidase 1 | CTSC | 4 | 2 | 6 | 3 | 4 | 1 | 2 | 1 | 0 | 1 | 2 | 2 | 3 | 1 | 3 | 3 | 2 | 1 | 2 | 3 |
| Q9H6S3 | Epidermal growth factor receptor kinase substrate 8-like protein | EPS8L2 | 3 | 6 | 2 | 4 | 4 | 1 | 0 | 0 | 2 | 1 | 2 | 1 | 2 | 0 | 2 | 1 | 5 | 7 | 10 | 3 |
| B1AHL2 | Fibulin 1 | FBLN1 | 5 | 11 | 19 | 16 | 4 | 1 | 18 | 4 | 9 | 3 | 8 | 1 | 7 | 5 | 3 | 3 | 1 | 1 | 1 | 1 |
| F5H4×1 | General vesicular transport factor p115 | USO1 | 2 | 4 | 2 | 5 | 4 | 1 | 4 | 3 | 2 | 3 | 4 | 3 | 3 | 1 | 3 | 1 | 3 | 5 | 0 | 2 |
| P35754 | Glutaredoxin-1 | GLRX | 4 | 4 | 4 | 3 | 4 | 2 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 0 | 2 | 2 | 1 | 2 | 2 | 3 |
| E9PB90 | Hexokinase-2 | HK2 | 2 | 2 | 2 | 4 | 4 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 3 | 3 | 3 | 2 | 2 | 1 | 4 | 3 |
| Q16270 | Insulin-like growth factor-binding protein 7 | IGFBP7 | 5 | 8 | 3 | 4 | 4 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | |
| P06756 | Integrin alpha-V | ITGAV | 4 | 6 | 6 | 4 | 4 | 1 | 0 | 3 | 2 | 2 | 9 | 1 | 4 | 3 | 3 | 2 | 1 | 1 | 0 | 1 |
| P19827 | Inter-alpha-trypsin inhibitor heavy chain H1 | ITIH1 | 4 | 4 | 2 | 2 | 4 | 4 | 1 | 1 | 1 | 1 | 6 | 2 | 3 | 1 | 3 | 1 | 0 | 3 | 3 | 2 |
| Q06033 | Inter-alpha-trypsin inhibitor heavy chain H3 | ITIH3 | 7 | 2 | 2 | 3 | 4 | 0 | 0 | 2 | 0 | 1 | 13 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 2 | 1 |
| Q63ZY3 | KN motif and ankyrin repeat domain-containing protein 2 | KANK2 | 2 | 4 | 3 | 4 | 4 | 1 | 5 | 5 | 6 | 3 | 7 | 3 | 1 | 6 | 3 | 1 | 1 | 2 | 2 | 2 |
| Q13751 | Laminin subunit beta-3 | LAMB3 | 3 | 5 | 3 | 5 | 4 | 2 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 4 | 1 | 0 | 1 |
| O75610 | Left-right determination factor 1 | LEFTY1 | 28 | 58 | 8 | 36 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 |
| O00292 | Left-right determination factor 2 | LEFTY2 | 18 | 49 | 6 | 29 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| P18428 | Lipopolysaccharide-binding protein | LBP | 4 | 6 | 2 | 4 | 4 | 2 | 1 | 0 | 1 | 1 | 2 | 2 | 1 | 0 | 2 | 0 | 0 | 2 | 5 | 2 |
| K7EJE8 | Lon protease homolog | LONP1 | 10 | 11 | 2 | 3 | 4 | 9 | 1 | 1 | 1 | 1 | 0 | 7 | 5 | 0 | 2 | 0 | 4 | 2 | 2 | 3 |
| P10253 | Lysosomal alpha-glucosidase | GAA | 6 | 6 | 2 | 3 | 4 | 1 | 3 | 3 | 2 | 3 | 2 | 4 | 0 | 2 | 3 | 2 | 3 | 0 | 8 | 3 |
| Q9HCC0 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial | MCCC2 | 3 | 4 | 4 | 3 | 4 | 2 | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 2 | 2 | 1 | 3 | 1 | 1 | 1 |
| P22570 | NADPH:adrenodoxin oxidoreductase, mitochondrial | FDXR | 9 | 5 | 8 | 4 | 4 | 2 | 0 | 1 | 3 | 2 | 1 | 1 | 0 | 3 | 1 | 5 | 7 | 1 | 1 | 2 |
| H0Y6T7 | Nicastrin (Fragment) | NCSTN | 3 | 2 | 3 | 2 | 4 | 2 | 2 | 1 | 2 | 3 | 2 | 2 | 2 | 1 | 3 | 2 | 2 | 2 | 1 | 3 |
| Q6XQN6 | Nicotinate phosphoribosyl transferase | NAPRT1 | 3 | 3 | 3 | 4 | 4 | 3 | 0 | 1 | 0 | 1 | 1 | 3 | 4 | 2 | 3 | 0 | 10 | 4 | 4 | 3 |
| Q9Y617 | Phosphoserine aminotransferase | PSAT1 | 8 | 16 | 10 | 10 | 4 | 0 | 1 | 0 | 2 | 1 | 0 | 5 | 3 | 8 | 3 | 1 | 0 | 0 | 0 | 0 |
| Q9Y446 | Plakophilin-3 | PKP3 | 8 | 10 | 2 | 2 | 4 | 2 | 0 | 0 | 0 | 1 | 0 | 9 | 0 | 1 | 1 | 0 | 4 | 8 | 10 | 3 |
| Q9UHX1 | Poly(U)-binding-splicing factor PUF60 | PUF60 | 3 | 4 | 2 | 3 | 4 | 0 | 3 | 1 | 0 | 1 | 1 | 8 | 4 | 6 | 3 | 2 | 3 | 2 | 0 | 3 |
| Q8NBJ5 | Procollagen galactosyltransferase 1 | GLT25D1 | 4 | 8 | 5 | 4 | 4 | 2 | 3 | 1 | 2 | 3 | 3 | 0 | 2 | 3 | 3 | 4 | 4 | 1 | 1 | 2 |
| Q02809 | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | PLOD1 | 11 | 15 | 3 | 4 | 4 | 0 | 1 | 1 | 3 | 1 | 0 | 0 | 6 | 3 | 2 | 0 | 4 | 1 | 1 | 1 |
| P25788 | Proteasome subunit alpha type-3 | PSMA3 | 4 | 2 | 2 | 2 | 4 | 2 | 4 | 1 | 1 | 2 | 1 | 4 | 2 | 2 | 3 | 2 | 1 | 7 | 4 | 3 |
| Q9P258 | Protein RCC2 | RCC2 | 5 | 5 | 3 | 4 | 4 | 1 | 5 | 3 | 6 | 3 | 1 | 1 | 9 | 7 | 2 | 4 | 9 | 4 | 1 | 3 |
| B4DJA5 | Ras-related protein Rab-5A | RAB5A | 4 | 4 | 2 | 2 | 4 | 2 | 4 | 1 | 2 | 3 | 1 | 3 | 1 | 2 | 2 | 1 | 0 | 2 | 2 | 2 |
| P61020 | Ras-related protein Rab-5B | RAB5B | 7 | 4 | 2 | 3 | 4 | 2 | 4 | 1 | 2 | 3 | 2 | 5 | 1 | 3 | 3 | 1 | 1 | 4 | 2 | 2 |
| Q9NQG5 | Regulation of nuclear pre-mRNA domain-containing protein 1B | RPRD1B | 5 | 3 | 2 | 2 | 4 | 2 | 2 | 1 | 1 | 2 | 1 | 4 | 4 | 5 | 3 | 2 | 6 | 2 | 1 | 3 |
| D6REQ6 | Ribonuclease T2 | RNASET2 | 5 | 8 | 2 | 2 | 4 | 1 | 2 | 1 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 1 | 3 | 3 |
| Q9Y230 | RuvB-like 2 | RUVBL2 | 3 | 4 | 2 | 2 | 4 | 0 | 2 | 2 | 0 | 2 | 1 | 2 | 2 | 4 | 3 | 3 | 0 | 2 | 1 | 2 |
| O00391 | Sulfhydryl oxidase 1 | QSOX1 | 2 | 11 | 3 | 8 | 4 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 11 | 14 | 1 | 2 |
| Q5T8U5 | Surfeit 4 | SURF4 | 3 | 2 | 2 | 2 | 4 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 2 | 1 |
| F6SKP1 | Transmembrane glycoprotein NMB | GPNMB | 3 | 2 | 6 | 2 | 4 | 3 | 2 | 0 | 0 | 2 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Q504Y1 | TRPM3 protein | TRPM3 | 6 | 4 | 2 | 5 | 4 | 5 | 4 | 5 | 1 | 3 | 4 | 6 | 0 | 4 | 3 | 2 | 0 | 0 | 2 | 2 |
| B1AH89 | Tubulin tyrosine ligase-like family, member 12 | TTLL12 | 3 | 8 | 2 | 4 | 4 | 2 | 3 | 0 | 3 | 3 | 1 | 7 | 2 | 3 | 3 | 2 | 4 | 4 | 1 | 3 |
| Q9Y224 | UPF0568 protein C14orf166 | C14orf166 | 4 | 4 | 2 | 2 | 4 | 1 | 0 | 1 | 3 | 1 | 1 | 3 | 4 | 4 | 3 | 1 | 5 | 4 | 2 | 3 |
| D6RGZ6 | Versican core protein (Fragment) | VCAN | 3 | 6 | 6 | 8 | 4 | 1 | 1 | 3 | 3 | 2 | 18 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Q6PCB0 | von Willebrand factor A domain-containing protein 1 | VWA1 | 5 | 2 | 2 | 5 | 4 | 1 | 1 | 2 | 3 | 2 | 3 | 0 | 1 | 2 | 2 | 2 | 0 | 0 | 1 | 1 |
| P04275 | von Willebrand factor | VWF | 4 | 2 | 5 | 5 | 4 | 0 | 2 | 4 | 1 | 2 | 7 | 1 | 1 | 3 | 2 | 1 | 0 | 2 | 2 | 2 |
| P36543 | V-type proton ATPase subunit E 1 | ATP6V1E1 | 2 | 3 | 3 | 2 | 4 | 1 | 2 | 3 | 2 | 3 | 1 | 4 | 1 | 2 | 2 | 2 | 2 | 0 | 2 | 3 |
| O75348 | V-type proton ATPase subunit G 1 | ATP6V1G1 | 2 | 2 | 2 | 2 | 4 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 2 | 2 | 3 | 0 | 2 | 0 | 2 | 2 |
OCCCa, ovarian clear cell carcinoma; OEmCa, ovarian endometrioid carcinoma; OSeCa, ovarian serous carcinoma; OMuCa, ovarian mucinous carcinoma.