Table 2. Logistic regression analysis of the factors associated with high-grade.
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| Odds ratio (CI) | P | Odds ratio (CI) | P | |
| Age (years) | 0.976 (0.933-1.021) | 0.291 | — | |
| Sex (male:female) | 1.733 (0.592-5.077) | 0.316 | — | |
| Body weight (kg) | 0.979 (0.926-1.034) | 0.438 | — | |
| Comorbidities | ||||
| Cardiovascular disease | 1.389 (0.234-8.240) | 0.718 | — | |
| Hypertension | 1.667 (0.483-5.751) | 0.419 | — | |
| Diabetes | 2.206 (0.448-10.87) | 0.331 | — | |
| Other cancer | 0.658 (0.069-6.267) | 0.716 | — | |
| Tumor size (cm) | 1.065 (0.793-1.431) | 0.675 | — | |
| Serum biomarkers | ||||
| Lactate (mmol/L) | 2.374 (1.275-4.421) | 0.006* | 2.890 (1.485-2.621) | 0.002* |
| LDH (mU/mL) | 1.001 (0.988-1.015) | 0.841 | — | |
| NGAL (ng/mL) | 1.297 (0.519-3.242) | 0.578 | — | |
| GFAP (mg/L) | 0.447 (0.095-2.103) | 0.308 | 0.245 (0.050-1.191) | 0.083 |
| NSE (ng/mL) | 0.997 (0.984-1.011) | 0.686 | — | |
| S100β (pg/mL) | 1.001 (0.997-1.004) | 0.789 | — | |
Abbreviations: HR, hazard ratio; CI, confidence interval; LDH, lactate dehydrogenase; NGAL, neutrophil gelatinase-associated lipocalin; GFAP, glial fibrillary acidic protein; NSE, neuron-specific enolase.
*p < 0.05.