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. 2017 Jul 10;8(38):63799–63812. doi: 10.18632/oncotarget.19124

Figure 7. tmTNF-α promotes AICD via forward and reverse signaling.

Figure 7

tmTNF-α expression is upregulated in activated T cells during AICD. tmTNF-α as a death ligand mediates apoptosis of activated T cells (1). Meanwhile, tmTNF-α as a receptor increases the sensitivity of activated T cells to sTNF-α- or tmTNF-α-induced apoptosis through upregulating TNFR1 or TNFR2, respectively (2). It can also augment the expression of FasL/Fas and TRAIL/DR4 to increase the sensitivity of activated T cells to AICD via reverse signaling (3).