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. 2017 Jul 10;8(38):63857–63870. doi: 10.18632/oncotarget.19148

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Copyright: © 2017 Wu et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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(A, B) PTN expression had no effect on the apoptosis of MG63 (A) and MG63/DOX (B) cells treated with DMSO. PTN knockdown promoted apoptosis in MG63 (A) and MG63/DOX (B) cells treated with DOX, while PTN overexpression inhibited apoptosis in MG63 cells treated with DOX. (C, D) PTN expression had no effect on the clone formation of MG63 (C) and MG63/DOX (D) cells treated with DMSO. PTN knockdown inhibited the clone formation of MG63 (C) and MG63/DOX (D) cells treated with DOX, while PTN overexpression promoted the clone formation of MG63 cells treated with DOX. *, p<0.05; **, p<0.01. PTN: pleiotrophin; OS: osteosarcoma; DOX: doxorubicin; sh: short hairpin; oe: overexpression. NS: not significant.