Figure 3. MiR-133b suppresses CRC tumorigenesis and metastasis in vivo.
HCT8 and HCT116 cells were transfected with miR-133b-mimic or scramble and then subcutaneously injected into nude mice. (A) in vivo subcutaneous tumor cell transplantation, the gross morphology of tumors are represented. (B, C) The statistical data for tumor volume (B) and tumor weight (C) are shown. (D) Representative image of hepatic metastatic sites. (E) Haptic metastatic tumor volume are shown. *P < 0.05, versus scramble control.