Table 3. Clinicopathological characteristics of patients according to the expression of PD-1.
| Characteristics | PD-1 positive | PD-1 negative | P |
|---|---|---|---|
| (N=77) | (N=263) | ||
| Gender | |||
| Male | 60(23.6%) | 194(76.4%) | 0.460 |
| Female | 17(19.8%) | 69(80.2%) | |
| Age | |||
| ≤45 | 11(50.0%) | 11(50.0%) | 0.002 |
| >45 | 66(20.8%) | 252(79.2%) | |
| WHO classification | |||
| Tubular adenocarcinoma | 51(20.9%) | 193(79.1%) | 0.124 |
| Signet ring cell | 13(36.1%) | 23(63.9%) | |
| Other | 13(21.7%) | 47(78.3%) | |
| Histological grade | |||
| low grade | 20(22.5%) | 69(77.5%) | 0.963 |
| high grade | 57(22.7%) | 194(77.3%) | |
| Tumor size | |||
| <5cm | 35(29.7%) | 83(70.3%) | 0.024 |
| ≥5cm | 42(18.9%) | 180(81.1%) | |
| Vascular invasion | |||
| Negative | 16(21.9%) | 57(78.1%) | 0.867 |
| Positive | 61(22.8%) | 206(77.2%) | |
| Neural invasion | |||
| Negative | 31(25.0%) | 93(75.0%) | 0.432 |
| Positive | 46(21.3%) | 170(78.07%) | |
| Depth of invasion | |||
| T1/T2 | 11(32.4%) | 23(67.6%) | 0.154 |
| T3/T4 | 66(21.6%) | 240(78.4%) | |
| Lymph metastasis | |||
| N0 | 13(20.0%) | 52(80.0%) | 0.571 |
| N1/N2/N3 | 64(23.3%) | 211(77.4%) | |
| Distant metastasis | |||
| M0 | 75(23.1%) | 250(76.9%) | 0.378 |
| M1 | 2(13.3%) | 13(86.7%) | |
| TNM stage | |||
| I-II | 24(25.0%) | 72(75.0%) | 0.516 |
| III-IV | 53(21.7%) | 191(78.3%) |