Table 5. Univariate and multivariate Cox regression test for PD-1 and PD-L1/L2 expression.
| Characteristics | Patient(N) | Death N (%) | HR(95%CI) | P | HR(95%CI)a | Pa |
|---|---|---|---|---|---|---|
| PD-1 in TIICs | ||||||
| Negative | 263 | 143(54.37) | 1.00 | 0.024 | 1.00 | 0.052 |
| Positive | 77 | 29(37.66) | 0.63(0.42-0.94) | 0.67(0.45-1.00) | ||
| PD-L1 in TCs | ||||||
| Negative | 203 | 110(54.19) | 1.00 | 0.150 | 1.00 | 0.075 |
| Positive | 137 | 62(45.25) | 0.80(0.58-1.09) | 0.74 (0.53-1.03) | ||
| PD-L1 in TIICs | ||||||
| Negative | 136 | 76(55.88) | 1.00 | 0.064 | 1.00 | 0.042 |
| Positive | 204 | 96(47.06) | 0.75(0.56-1.02) | 0.72(0.53-0.99) | ||
| PD-L1 overall | ||||||
| Negative | 124 | 69(55.64) | 1.00 | 0.094 | 1.00 | 0.058 |
| Positive | 216 | 103(47.69) | 0.77(0.57-1.05) | 0.74(0.54-1.01) | ||
| PD-L2 in TCs | ||||||
| Negative | 183 | 92(50.27) | 1.00 | 0.919 | 1.00 | 0.820 |
| Positive | 157 | 80(50.96) | 1.02(0.75-1.37) | 0.97(0.71-1.31) | ||
| PD-L2 in TIICs | ||||||
| Negative | 133 | 64(48.12) | 1.00 | 0.452 | 1.00 | 0.342 |
| Positive | 207 | 108(52.17) | 1.13(0.83-1.53) | 1.16(0.85-1.59) | ||
| PD-L2 overall | ||||||
| Negative | 117 | 56(47.86) | 1.00 | 0.352 | 1.00 | 0.366 |
| Positive | 223 | 116(52.02) | 1.16(0.85-1.60) | 1.16(0.84-1.60) | ||
| PD-1/PD-L1 pathway | ||||||
| none of PD-1/PD-L1(+) | 91 | 55(60.43) | 1.00 | 1.00 | ||
| one of PD-1/PD-L1 (+) | 204 | 101(49.51) | 0.74 (0.53-1.03) | 0.071 | 0.70(0.50-0.99) | 0.043 |
| both of PD-1/PD-L1(+) | 45 | 16(35.56) | 0.47(0.27-0.83) | 0.009 | 0.48(0.27-0.84) | 0.010 |
| PD-1/PD-L2 pathway | ||||||
| none of PD-1/PD-L2(+) | 92 | 45(48.91) | 1.00 | 1.00 | ||
| one of PD-1/PD-L2 (+) | 195 | 108(55.38) | 1.22(0.86-1.73) | 0.257 | 1.20(0.84-1.70) | 0.323 |
| both of PD-1/PD-L2(+) | 53 | 19(35.85) | 0.71(0.41-1.21) | 0.203 | 0.75(0.44-1.28) | 0.289 |
| PD-1 & PD-L1/L2 pathway | ||||||
| none of PD-1& PD-L1/L2 pathway(+) | 274 | 146(53.28) | 1.00 | 1.00 | ||
| at least one of the two pathway(+) | 66 | 26(30.39) | 0.67(0.44-1.02) | 0.064 | 0.68(0.45-1.04) | 0.076 |
HR: Hazard ratio a: 95%CI and P values were calculated with multivariate Cox regression with the enter method including the variables that P<0.05 from the univariate analysis, such as tumor size, vascular invasion, neural invasion and TNM stage.