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. 2017 Jul 18;8(38):64114–64128. doi: 10.18632/oncotarget.19342

Figure 6. Effects of the miR-708 inhibitor and/or 5-aza on the methylation state of the DKK3 promoter.

Figure 6

(A) Genomic structure of the DKK3 gene and locations of the primers used in this study. (B) Detection of the unmethylated and methylated statuses of the DKK3 gene using the MSP method. (C and D) Methylation status of the DKK3 gene promoter region in CpG islands in Nalm- 6 (C) and BALL-1 (D) cells treated with the miR-708 inhibitor and/or 5-aza, as determined by sequencing after bisulfite modification of the genomic DNA. The solid spots means methylated CpG dinucleotide, the hollow spots means unmethylated CpG dinucleotide.