Table 1. The single-nucleotide polymorphisms (SNPs) analyzed in this study.
Class | SNP | Position (hg38) (bp) | Candidate gene | Allele | Minor allele frequencies (MAF) | HWE | |||
---|---|---|---|---|---|---|---|---|---|
Major | Minor | EUR | JPT | TWB | |||||
1 | rs11900673 | chr2:62225526 | B3GNT2 | C | T | 0.13 | 0.33 | 0.18 | 0.28 |
1 | rs657075 | chr5:132094425 | CSF2 | G | A | 0.13 | 0.38 | 0.25 | 0.46 |
1 | rs12529514 | chr6:14096427 | CD83 | T | C | 0.06 | 0.13 | 0.23 | 0.78 |
1 | rs2233434 | chr6:44265183 | NFKBIE | T | C | 0.04 | 0.22 | 0.16 | 0.52 |
1 | rs10821944 | chr10:62025330 | ARID5B | T | G | 0.31 | 0.33 | 0.27 | 0.59 |
1 | rs3781913 | chr11:72662452 | PDE2A-ARAP1 | A | C | 0.56 | 0.29 | 0.28 | 0.74 |
1 | rs2841277 | chr14:104924668 | PLD4 | T | C | 0.52 | 0.30 | 0.42 | 0.24 |
1 | rs2847297 | chr18:12797695 | PTPN2 | A | G | 0.32 | 0.35 | 0.30 | 0.29 |
2 | rs11209032 | chr1:67274409 | IL23R | G | A | 0.33 | 0.41 | 0.49 | 0.86 |
2 | rs4672495 | chr2:62294109 | T | G | 0.32 | 0.12 | 0.17 | 0.86 | |
2 | rs10865331 | chr2:62324337 | G | A | 0.38 | 0.27 | 0.49 | 0.60 | |
2 | rs27434 | chr5:96793809 | ERAP1 | A | G | 0.79 | 0.52 | 0.47 | 0.40 |
2 | rs3734523 | chr6:25925759 | SLC17A2 | G | A | 0.09 | 0.00 | 0.03 | 0.38 |
2 | rs13202464 | chr6:31376806 | HLA-B | A | G | 0.06 | 0.18 | 0.07 | 0.55 |
2 | rs13210693 | chr6:109277761 | G | A | 0.53 | 0.56 | 0.48 | 0.97 |
EUR, European; JPT, Japanese in Tokyo; TWB, Taiwan biobank; HWE, p value for Hardy-Weinberg equilibrium test in TWB.
SNPs of class 1 and class 2 were extracted from Okada et al. (2012) [21] and Wen et al. (2014) [29], respectively.
MAFs of EUR and JPT were extracted from NCBI; MAFs of TWB were obtained from the Taiwan View website (https://taiwanview.twbiobank.org.tw/index). Miner allele was determined by MAF of TWB.