Figure 1. A higher methylation level of GATA3, IL-4 and TGF-β is detected in CD4⁺ T cells from active BD patients (n=16) when compared healthy controls (n=18).

Methylation levels of the CpG-7. 8.9 unit in GATA3 (A), CpG-2 in IL-4 (B), as well as CpG-2.3.4.5 (C) and CpG-10.11 (D) in TGF-β were all significantly up-regulated in BD patients compared to that in healthy controls. Data represent mean ± SEM. * P < 0.05, ** P < 0.01, *** P < 0.001.