Table 1. Demographics, clinicopathologic characteristics of patients and univariate analysis in training cohort.
| NSCLC(N=4220) | SCLC(N=643) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Training set(N=2954) | Validation(N=1266) | Training set (N=450) | Validation(N=193) | ||||||
| Cases (%) | OS(months)Median(95%CI) | P | Cases (%) | Cases (%) | OS(months)Median(95%CI) | P | Cases (%) | ||
| Gender | Male | 2365 | 26.8(25.8-28.3) | 0.672 | 1012 | 376 | 19.4(17-22.7) | 0.099 | 42 |
| Female | 589 | 29.3(25.6-32.4) | 254 | 74 | 21.0(16-47.0) | 151 | |||
| Age, years | <60 | 1935 | 27.0(25.8-28.9) | 0.095 | 814 | 305 | 20.0(17.8-25.0) | 0.241 | 132 |
| 60-70 | 831 | 24.8(20.4-32.0) | 77 | 121 | 19.2(16.8-23.0) | 51 | |||
| >70 | 188 | 27.4(25.7-32.0) | 375 | 24 | 14.5(10.0-26.0) | 10 | |||
| Smoking habit, pack-y | <30 | 1048 | 26.9(24.9-29.0) | 0.727 | 633 | 218 | 19.4(17.0-25.0) | 0.584 | 113 |
| 30-40 | 633 | 26.5(24.0-29.9) | 241 | 126 | 19.5(16.0-26.0) | 47 | |||
| >40 | 516 | 28.9(26.7-34.6) | 392 | 106 | 20.0(16.4-24) | 33 | |||
| Occupation | Enterprise or company employee/worker | 662 | 30.5(26.7-36.0) | 252 | 78 | 16.0(14-20.0) | 41 | ||
| Farmer | 1027 | 24.3(22.3-26.9) | 0.003 | 432 | 184 | 21.9(18-26.0) | 0.478 | 70 | |
| Public sector employee | 960 | 27.2(24.7-30.6) | 435 | 135 | 20.0(17-25.2) | 55 | |||
| Freelance or self-employed | 157 | 28.9(25.1-45.3) | 76 | 26 | 25.5(19-50.0) | 16 | |||
| Others | 148 | 32.4(25.9-51.7) | 71 | 27 | 19.0(15-NA) | 11 | |||
| Education | Primary school or below | 666 | 26.9(24.1-31.8) | <0.001 | 284 | 106 | 19.0(15.7-28.0) | 0.002 | 45 |
| Junior and Senior high school | 1682 | 28.3(26.7-30.6) | 715 | 249 | 23.0(20.0-26.0) | 103 | |||
| Undergraduate or over | 436 | 28.5(23.0-36.0) | 189 | 59 | 17.4(15.9-25.0) | 26 | |||
| Health insurance | New rural cooperative medical scheme | 538 | 28.3(25.8-32.0) | 225 | 105 | 25.0(22.0-35) | 46 | ||
| Urban residents basic medical insurance | 210 | 37.7(29.3-49.0) | <0.001 | 92 | 36 | 23.4(14.0-47) | 0.002 | 15 | |
| Urban employees basic medical insurance | 1013 | 32.8(29.4-37.3) | 416 | 142 | 19.4(16.2-25) | 48 | |||
| Self pay | 707 | 25.6(21.6-28.1) | 323 | 102 | 19.0(15.0-25) | 46 | |||
| Other | 486 | 20.4(18.0-23.6) | 210 | 65 | 14.2(11.3-18) | 38 | |||
| Clinical T stage | T1 | 260 | 37.2(30.5-52.2) | <0.001 | 91 | — | — | — | — |
| T2 | 1510 | 32.3(29.3-36.3) | 653 | — | — | — | — | ||
| T3 | 547 | 23.1(19.9-26.7) | 241 | — | — | — | — | ||
| T4 | 637 | 20.4(18.3-22.4) | 281 | — | — | — | — | ||
| Clinical N stage | N0 | 909 | 51.8(48.2-60.5) | <0.001 | 361 | — | — | — | — |
| N1 | 369 | 38.6(30.6-47.0) | 164 | — | — | — | — | ||
| N2 | 934 | 23.0(20.7-24.6) | 417 | — | — | — | — | ||
| N3 | 742 | 17.4(15.5-19.2) | 324 | — | — | — | — | ||
| Clinical M stage | M0 | 2022 | 36.1(33.1-38.6) | <0.001 | 852 | — | — | — | — |
| M1 | 932 | 15.6(14.8-17.8) | 414 | — | — | — | — | ||
| Clinical stage | —/ Limited | — | — | — | — | 254 | 21(19-24.8) | 0.069 | 105 |
| —/ Extensive | — | — | — | — | 196 | 17(15-22.0) | 88 | ||
| Tumor location | Right upper lobe | 726 | 32.2(28.5-36.5) | <0.001 | 344 | 89 | 19.4(14.0-25.0) | 0.668 | 34 |
| Right middle lobe | 152 | 31.0(24.6-48.0) | 59 | 26 | 19.0(16.2-48.7) | 8 | |||
| Right lower lobe | 435 | 31.2(25.9-39.7) | 180 | 53 | 20.0(14.2-30.9) | 30 | |||
| Left upper lobe | 699 | 27.2(24.9-31.7) | 294 | 104 | 22.0(17.8-29.3) | 49 | |||
| Left lower lobe | 426 | 29.0(26.2-35.8) | 166 | 57 | 16.9(13.2-29.0) | 23 | |||
| Othersa | 516 | 18.9(16.2-20.6) | 223 | 121 | 19.0(16.0-25.2) | 49 | |||
| Central location | Central | 517 | 23.8(21.6-25.2) | <0.001 | 225 | 88 | 19.0(16.2-22) | 0.573 | 46 |
| Peripheral | 1431 | 34.0(30.6-39.0) | 593 | 308 | 25.6(21.8-49) | 130 | |||
| Unknownb | 1006 | 32.2(26.6-38.6) | 448 | 54 | 19.4(15.7-27) | 17 | |||
| Pathological types | Adenocarcinoma | 938 | 25.4(23.4-27.9) | 0.002 | 392 | — | — | — | — |
| Squamous carcinom | 1683 | 27.7(26.3-30.6) | 722 | — | — | — | — | ||
| Adenosquamous carcinoma | 120 | 45.2(37.9-58.9) | 55 | — | — | — | — | ||
| Other | 213 | 23.2(18.1-28.5) | 97 | — | — | — | — | ||
| Differentiation | High | 181 | 51.3(36.2-66.8) | <0.001 | 81 | — | — | — | — |
| Moderate | 866 | 38.1(35.4-43.4) | 355 | — | — | — | — | ||
| Low | 663 | 21.9(19.3-24.0) | 292 | — | — | — | — | ||
| Undifferentiated | 558 | 19.2(17.3-21.3) | 257 | — | — | — | — | ||
| Diagnostic method | Biopsy | 1476 | 20.7(19.3-22.3) | 614 | 387 | 20.0(17.8-23.0) | 0.054 | 171 | |
| Surgery | 1085 | 60.4(53.9-67.5) | <0.001 | 451 | 23 | 34.0(21.8-NA) | 8 | ||
| Cytology | 393 | 14.6(12.6-16.6) | 201 | 40 | 12.4(7.6-34.1) | 14 | |||
| Therapeutic regimen | Simple chemotherapy | 1131 | 18.3(16.9-19.5) | 490 | 238 | 17.4(15.0-22.0) | 104 | ||
| Surgery/Radiotherapy/Chemotherapy | 137 | 43.9(38.6-54.0) | <0.001 | 49 | — | — | — | ||
| Surgery/ Radiotherapy | 87 | 32.3(23.5-42.1) | 42 | — | — | — | |||
| Surgery/ Chemotherapy | 434 | 79.6(68.3-NA) | 203 | — | — | — | |||
| Radiotherapy / Chemotherapy | 449 | 22.3(20.4-25.7) | 190 | 171 | 21.0(18.0-25.7) | 0.051 | 72 | ||
| Simple surgery | 488 | 57.0(51.0-75.6) | 175 | — | — | — | |||
| Simple radiotherapy | 197 | 18.0(14.4-24.3) | 105 | 16 | 18.4(6.97-NA) | 7 | |||
| Others | 31 | 14.9(8.93-21.2) | 12 | 25 | 34.0(25.23-NA) | 10 | |||
NSCLC, non-small-cell lung cancer; SCLC, small-cell lung cancer; OS, overall survival.
a: Tumors locating at two or more lobes were named “other”.
b: Tumors which could not be distinguished as central or peripheral were named “unknown”.