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. 2017 May 12;8(38):64344–64357. doi: 10.18632/oncotarget.17834

Figure 1. NK cells are required to reduce BPTF KD 67NR and 66cl4 tumor weight.

Figure 1

(A) BPTF Western blot analysis from control (Ctrl-sh1, Ctrl-sh2) and BPTF KD (Bptf-sh1, Bptf-sh2) 67NR and 66cl4 total cell extracts. Cyclophilin B is used as a loading control. (B) 67NR and 66cl4 tumor weights harvested from BALB/c mice (n ≥ 11 biological replicates, * = ttest pvalue < 0.003). (C) Low resolution KEGG pathway analysis of 67NR and 66cl4 significantly deregulated genes highlighting clusters of genes with function in the immune system (For high resolution please refer to Supplementary Figure 2B). (D) 67NR and 66cl4 tumor weights harvested from NSG mice (n = 9 biological replicates). (E) 67NR and 66cl4 tumor weights harvested from undepleted, or CD8, CD4 or asialo-GM1 mAb depleted BALB/c mice (n = 6 biological replicates, * = ttest pvalue < 0.05). Some dots overlap.