Table 3. Logistic analyses of SNPs association with alcohol-induced ONFH in without adjustment addition.
| SNP | Model | Genotype | Control | Alcohol | OR (95% CI) | p |
|---|---|---|---|---|---|---|
| rs1053605 | Codominant | C/C | 242 (78.6%) | 232 (77.3%) | 1 | 0.57 |
| C/T | 63 (20.4%) | 62 (20.7%) | 1.03 (0.69-1.52) | |||
| T/T | 3 (1%) | 6 (2%) | 2.09 (0.52-8.44) | |||
| Dominant | C/C | 242 (78.6%) | 232 (77.3%) | 1 | 0.71 | |
| C/T-T/T | 66 (21.4%) | 68 (22.7%) | 1.07 (0.73-1.58) | |||
| Recessive | C/C-C/T | 305 (99%) | 294 (98%) | 1 | 0.29 | |
| T/T | 3 (1%) | 6 (2%) | 2.07 (0.51-8.37) | |||
| Overdominant | C/C-T/T | 245 (79.5%) | 238 (79.3%) | 1 | 0.95 | |
| C/T | 63 (20.4%) | 62 (20.7%) | 1.01 (0.68-1.50) | |||
| Log-additive | --- | --- | --- | 1.11 (0.79-1.58) | 0.54 | |
| rs243849 | Codominant | C/C | 216 (70.1%) | 191 (63.7%) | 1 | 0.11 |
| C/T | 83 (26.9%) | 92 (30.7%) | 1.25 (0.88-1.79) | |||
| T/T | 9 (2.9%) | 17 (5.7%) | 2.14 (0.93-4.90) | |||
| Dominant | C/C | 216 (70.1%) | 191 (63.7%) | 1 | 0.09 | |
| C/T-T/T | 92 (29.9%) | 109 (36.3%) | 1.34 (0.95-1.88) | |||
| Recessive | C/C-C/T | 299 (97.1%) | 283 (94.3%) | 1 | 0.092 | |
| T/T | 9 (2.9%) | 17 (5.7%) | 2.00 (0.88-4.55) | |||
| Overdominant | C/C-T/T | 225 (73%) | 208 (69.3%) | 1 | 0.31 | |
| C/T | 83 (26.9%) | 92 (30.7%) | 1.20 (0.84-1.70) | |||
| Log-additive | --- | --- | --- | 1.34 (1.01-1.78) | 0.044 | |
| rs243847 | Codominant | T/T | 109 (35.4%) | 118 (39.3%) | 1 | 0.47 |
| C/T | 140 (45.5%) | 134 (44.7%) | 0.88 (0.62-1.26) | |||
| C/C | 59 (19.2%) | 48 (16%) | 0.75 (0.47-1.19) | |||
| Dominant | T/T | 109 (35.4%) | 118 (39.3%) | 1 | 0.31 | |
| C/T-C/C | 199 (64.6%) | 182 (60.7%) | 0.84 (0.61-1.17) | |||
| Recessive | T/T-C/T | 249 (80.8%) | 252 (84%) | 1 | 0.31 | |
| C/C | 59 (19.2%) | 48 (16%) | 0.80 (0.53-1.22) | |||
| Overdominant | T/T-C/C | 168 (54.5%) | 166 (55.3%) | 1 | 0.85 | |
| C/T | 140 (45.5%) | 134 (44.7%) | 0.97 (0.70-1.33) | |||
| Log-additive | --- | --- | --- | 0.87 (0.70-1.09) | 0.22 | |
| rs243832 | Codominant | G/G | 122 (39.6%) | 116 (38.7%) | 1 | 0.68 |
| G/C | 145 (47.1%) | 150 (50%) | 1.09 (0.77-1.53) | |||
| C/C | 41 (13.3%) | 34 (11.3%) | 0.87 (0.52-1.47) | |||
| Dominant | G/G | 122 (39.6%) | 116 (38.7%) | 1 | 0.81 | |
| G/C-C/C | 186 (60.4%) | 184 (61.3%) | 1.04 (0.75-1.44) | |||
| Recessive | G/G-G/C | 267 (86.7%) | 266 (88.7%) | 1 | 0.46 | |
| C/C | 41 (13.3%) | 34 (11.3%) | 0.83 (0.51-1.35) | |||
| Overdominant | G/G-C/C | 163 (52.9%) | 150 (50%) | 1 | 0.47 | |
| G/C | 145 (47.1%) | 150 (50%) | 1.12 (0.82-1.55) | |||
| Log-additive | --- | --- | --- | 0.98 (0.77-1.24) | 0.85 | |
| rs7201 | Codominant | A/A | 173 (56.4%) | 178 (59.3%) | 1 | 0.51 |
| C/A | 116 (37.8%) | 110 (36.7%) | 0.92 (0.66-1.29) | |||
| C/C | 18 (5.9%) | 12 (4%) | 0.65 (0.30-1.39) | |||
| Dominant | A/A | 173 (56.4%) | 178 (59.3%) | 1 | 0.46 | |
| C/A-C/C | 134 (43.6%) | 122 (40.7%) | 0.88 (0.64-1.22) | |||
| Recessive | A/A-C/A | 289 (94.1%) | 288 (96%) | 1 | 0.29 | |
| C/C | 18 (5.9%) | 12 (4%) | 0.67 (0.32-1.41) | |||
| Overdominant | A/A-C/C | 191 (62.2%) | 190 (63.3%) | 1 | 0.78 | |
| C/A | 116 (37.8%) | 110 (36.7%) | 0.95 (0.69-1.32) | |||
| Log-additive | --- | --- | --- | 0.87 (0.66-1.14) | 0.31 |
Values in bold indicate that the locus has statistically significant.