Table 3. Multivariate Cox regression analysis for NC and NP (N=378).
| Prognostic factors | NC Model* | NP Model* | ||
|---|---|---|---|---|
| Adjusted HR (95%CI) | P value | Adjusted HR (95%CI) | P value | |
| Gender (female vs. male) | 1.358(1.069∼1.725) | 0.012 | 1.356(1.068∼1.723) | 0.012 |
| Age | 1.002(0.992∼1.012) | 0.711 | 0.998 (0.989∼1.008) | 0.764 |
| Primary tumor site | 0.915(0.821∼1.019) | 0.105 | 0.905(0.812∼1.007) | 0.068 |
| Tumor stage (IV vs. III) | 4.410(2.037∼9.543) | <0.001 | 4.303(1.990∼9.303) | <0.001 |
| Family history (Yes vs. No) | 0.994(0.768∼1.287) | 0.967 | 1.026(0.793∼1.327) | 0.846 |
| Nutrient (Abnormal vs. Normal) | 1.219(0.948∼1.567) | 0.122 | 1.183(0.919∼1.525) | 0.192 |
| ECOG | 1.658(1.294∼2.124) | <0.001 | 1.621(1.264∼2.078) | <0.001 |
| Comorbidity (Yes vs. No) | 0.860(0.663∼1.116) | 0.256 | 0.893(0.689∼1.158) | 0.394 |
| Palliative care(BSC vs PCR) | 1.012(0.778∼1.315) | 0.930 | 1.033(0.795∼1.342) | 0.808 |
| Albumin | 0.961(0.942∼0.981) | <0.001 | 0.958(0.938∼0.978) | <0.001 |
| LDH | 0.513(0.400∼0.657) | <0.001 | 0.475(0.372∼0.605) | <0.001 |
| NC (HNC vs. LNC) | 1.828(1.409∼2.371) | <0.001 | - | - |
| NP(HNP vs. LNP) | - | - | 1.475(1.106∼1.967) | 0.008 |
Abbreviation: NC, neutrophil counts; NP, neutrophil percentages; HR: hazard ratio; CI: confidence interval; LNC: low NC (pretreatment NC<=8); HNC, high NC (pretreatment NC>8); LNP, low NP (pretreatment NP<=0.85); HNP, high NP (pretreatment NP>0.85); BSC, best supportive care; PCR, palliative chemoradiotherapy; ECOG, Eastern Cooperative Oncology Group.
* The potential prognostic factors used for adjustment in Cox regression model include: Age; Gender; Family history; Nutrient status; ECOG; Primary tumor site; Tumor stage; Comorbidity, Palliative care; Albumin; LDH.