Table 4. Adjusted HRs for overall survival stratified by changes in NC and NP in cohort 2 (N = 106).
| NC | NC Model* | NP | NP Model* | ||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Descending | Reference | Descending | Reference | ||
| Ascending | 1.837(1.096∼3.079) | 0.021 | Ascending | 3.268(1.848∼5.778) | <0.001 |
| LNC→LNC | Reference | LNP→LNP | Reference | ||
| LNC→HNC | 2.772(1.560∼4.928) | 0.001 | LNP→HNP | 7.536(3.610∼15.73) | <0.001 |
| HNC→LNC | 0.429(0.110∼1.673) | 0.223 | HNP→LNP | 0.421(0.087∼2.038) | 0.282 |
| HNC→HNC | 2.537(1.030∼6.249) | 0.043 | HNP→HNP | 2.497(0.545∼11.44) | 0.239 |
Abbreviation: NC, neutrophil counts; NP, neutrophil percentages; HR: hazard ratio; CI: confidence interval; LNC: low NC (pretreatment NC<=8); HNC, high NC (pretreatment NC>8); LNP, low NP (pretreatment NP<=0.85); HNP, high NP (pretreatment NP>0.85).
* The potential prognostic factors used for adjustment in Cox regression model include: Age; Gender; Family history; Nutrient status; ECOG; Primary tumor site; Tumor stage; Comorbidity, Palliative care; Albumin; LDH.