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. 2017 May 16;8(38):64534–64550. doi: 10.18632/oncotarget.17885

Figure 1. Structure of the HMGB1 protein.

Figure 1

(A) The 5 exons of human HMGB1 gene are indicated by boxes (hollow for translated regions and solid for un-translated regions). (B) The human HMGB1 protein has 215 amino acid residues and is composed of three domains: A box, B box and an acidic C-terminal tail. There are three redox-sensitive cysteine residues at positions 23, 45, and 106, which regulate HMGB1 function in response to oxidative stress. (C) The human HMGB1 is loosely and transiently associated with nucleosomes. In this location, HMGB1 is important for spatial segregation and nuclear homeostasis.