Appendix 2—video 3. 3D modeling of HF growth pattern evolution with head-to-tail hair cycle asynchrony.
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Initial asynchrony was introduced into the field by assigning a group of HFs on one end with a one-time increase in activator ligands. Simulations faithfully reproduce head-to-tail asynchrony of the first cycle. However, this asynchrony fails to degrade quickly, and persists during multiple consecutive cycles. This differs from rapid HF growth pattern evolution observable in mice. Also see Appendix 2—figure 15.