Appendix 1—figure 4. Downregulation of WNT leads to hair length shortening.
Krt14-Cre;Wnt7bfl/fl mice display prominent pelage shortening during the first cycle (A’), which then becomes largely restored during the second cycle (A). Indeed, second cycle hairs in the same mutant HFs are ~15–23% longer than first cycle hairs (B’). Note that hairs on B) were dyed red. In Krt5-rtTA;tetO-Dkk1 mice, induction of Dkk1 results in prominent pelage shortening (A’’) and individual hair shorten by 22–25% as compared to non-induced control (B’’). Scale bars: B-B’’ – 1 mm. Images on B-B’’ are composites.