Table 1. Recently defined FMRP genetic functions.

The table lists recently validated roles of FMRP (column 1), the FXS model system of the work (column 2), and the primary reference(s) discussed in the text (column 3).

Proposed FMRP Roles	FXS Model	References
mRNA-binding translational regulator; canonically suppressing translation	Mouse and Drosophila	[2,33,34,46]
Chromatin-binding; regulates genome stability, required for early DDR	Drosophila and Mouse	[4,5]
ADAR-binding RNA editing regulator; alters RNA editing of neural genes	Drosophila, Zebrafish, Mouse	[6,7]
RBM14-binding in pre-mRNA splicing; promotes mRNA target binding	Mouse	[8]
microRNA pathway regulation; neural circuit plasticity and behavioral output	Drosophila	[9,10]
Regulation of cell differentiation kinetics; effects both neurons and glia	Mouse	[14]
Ion channel-binding to regulate gating; circuit excitability and plasticity	Mouse	[16,17]