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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Biomaterials. 2017 Aug 15;145:44–55. doi: 10.1016/j.biomaterials.2017.08.025

Figure 1.

Figure 1

Biomimetic design of the GSSR5 composites. Silicatein mediates the formation of biosilica particles within the siliceous spicules which is organized by collagen in sponge (A). Biomimetic self-assembly of biosilica particles on the silk templates catalyzed by the biosilica selective peptide R5 (B). Schematic representation of the biomimetic GSSR5 composites and fluorescence microscopy image showing the gradient of FITC-labeled R5 peptide along the longitudinal direction of the composites (C). The high region contains a high content of the R5 peptide and biosilica particles in contrast to the transition to the medium and low regions where the contents diminish. Gross appearance of the GSSR5 composites (D). Molar ratio of R5/silk in the GSSR5 composites (E), showing gradually increasing concentration of the R5 peptide from the low to the high R5 peptide loading regions in the gradient composites. Scale bar, 2 mm.