Scatter plots depicting the percent of lost (A), deactivated (B), static (C), activated (D), and gained (E) anchors that overlap TF footprints and the −log 10 p-value of enrichment (Fisher’s Exact Test) for each TF. (F) Percent of loop anchors that overlap an AP-1 footprint as a function of loop subset and promoter or enhancer overlap (G) RNA fold-change of genes connected via a loop to distal TF footprints. FOS, JUN, and MAF points represent individual FOS-, JUN-, and MAF-related TF footprints. Log2 fold-changes were median normalized to account for the fact that genes at loop anchors exhibited a shift towards upregulation during differentiation. (H) 20 randomly chosen interaction communities containing a gained loop are shown. Loop anchors containing AP-1 footprints are indicated in green. See also Figure S5.