Figure 1.

Concentration–response curves of 5‐HMF‐induced vasodilation in porcine coronary arteries with either intact or denuded endothelium. Rings were precontracted with the thromboxane mimetic U‐46619 (50 nM) and cumulative concentration–response curves to 5‐HMF were established. Effective denudation of the endothelium was confirmed by a lack of relaxation to bradykinin (1 μM; inset). Concentration–response curves established with different ring segments from a single heart were averaged and counted as an individual experiment. Data are mean values ± SEM of six hearts.