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. 2017 Sep 22;7:12219. doi: 10.1038/s41598-017-12500-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Forest plots of intra-operative main complications. TTDC reduce the risk of intra-operative arrhythmias in cohort studies (A), and has non-significant effect in case control (B). Furthermore, there is no significant difference in intra-operative aortic valve insufficiency (C) and residual shunts (D) between TTDC and COHS in cohort studies. However, results of cohort studies showed a higher risk in intra-operative residual shunts in TTDC (E).