Table 2.
Purinergic receptor expression in cultured cells (references in Table 1)
| Cell type | Receptors expressed | ||
|---|---|---|---|
| P2X | P2Y | P1 | |
| Vascular endothelial cells | P2X4, P2X5, P2X7 | P2Y1,2 and 12 | A1 |
| Airways | |||
| Lung epithelial cells | P2X4, P2X5 | P2Y1,2,4,6 and 11 | A1, A2A, A2B |
| Nasal epithelial cells | P2Y2, P2Y6, P2Y11 | A2B | |
| Tracheal epithelial cells | P2X4, P2X7 | P2Y1, P2Y2 | A2B |
| Eye | |||
| Retinal ganglion cells | P2X2-7 | A1, A2A, A3 | |
| Retinal pigment cells | P2X2, P2X3, P2X7 | P2Y2 | A1, A2A, A2B, A3 |
| Retinal glial (Müller) cells | P2X7 | P2Y1 | A1 |
| Lens | P2X1, P2X4 | A1 | |
| Ciliary epithelial cells | P2X2, P2X3, P2X7 | P2Y2 | A1, A2A, A2B, A3 |
| Trabecular meshwork cells | P2X1, P2X7 | A1 | |
| Corneal endothelial cells | P2X4-7 | P2Y1,2,4 and 6 | |
| Liver | |||
| Hepatocytes | P2X4, P2X7 | P2Y1,2,4 and 6 | A2A, A2B, A3 |
| Biliary epithelium (cholangiocytes) | P2X4 | P2Y1,2,4,6,11,12 and 13 | A2A |
| Glial cells | |||
| Astrocytes | P2X4, P2X7 | P2Y1, P2Y2 | A1, A2A, A3 |
| Astrocytoma cells | P2X7 | P2Y1, P2Y2 | A2A, A2B, A3 |
| Microglia | P2X4, P2X7 | P2Y1, P2Y11, P2Y12 | A1, A2A, A2B |
| Bladder urothelial cells | P2X2, P2X3, P2X4 | P2Y1,2,4 and 6 | A1 |
| Muscle | |||
| Vascular smooth muscle | P2X1, P2X2, P2X4 | P2Y1,2,4 and 6 | A2A, A2B, A3 |
| Bladder smooth muscle | P2X1, P2X2 | P2Y2, P2Y6 | A1, A2A, A2B |
| Cardiomyoctes | P2X1,3,4,5,6 and 7 | P2Y1, P2Y2 | A1, A2A, A2B |
| Fibroblasts | |||
| Fibroblasts | P2X7 | P2Y2 | A2A, A2B |
| Cardiac fibroblasts | P2X4, P2X7 | P2Y2 | A1, A2A, A2B, A3 |
| Bone | |||
| Bone marrow stromal cells | P2X7 | P2Y1,2,6 and 11 | A2B |
| Periodontal ligament | P2Y1,2,4 and 6 | A2A | |
| Osteoblastic cells | P2X1-7 | P2Y1,2,4,6,12,13 and 14 | A2A, A2B |
| Intervertebral disc annulus cells | P2X4, P2X7 | ||
| Chondrocytes | P2X1,3,4,5 and 7 | P2Y2 | A2A, A2B |
| MLO-Y4 osteocytes | P2X1,2,3,4 and 7 | P2Y2,4,12 and 13 | |
| Immune cells | |||
| Jurkat T lymphocytes | P2X1,4,5 and 7 | A1, A2A, A2B, A3 | |
| B lymphoblasts | A2A | ||
| Neutrophils | P2X1, P2X4, P2X7 | P2Y2,4,6 and 11 | A1, A2A, A2B, A3 |
| Mast cells | P2X7 | P2Y1, P2Y2 | A2A, A2B, A3 |
| Macrophages | P2X7 | P2Y2, P2Y6 | A2A, A2B |
| Tumour cells | |||
| Prostate cancer cells | P2X4-7 | P2Y1,2,6 and 11 | A1, A2A, A2B, A3 |
| Hepatoma cells | P2Y1,2,4,6 and 13 | A2A, A2B, A3 | |
| Cholangiocarcinoma | P2Y2 | ||
| Lung epithelial carcinoma (A549) cells | P2X4-7 | P2Y2, P2Y4, P2Y6 | A2A, A2B, A3 |
| Mammary carcinoma cells | P2X7 | P2Y1 | A1, A2A, A3 |
| Ehrlich ascites tumour cells | P2Y1, P2Y2 | ||
| Ovarian carcinoma (SKOV-3) cells | P2X7 | P2Y2, P2Y6 | |
| L929 fibrosarcoma cells | P2X7 | ||
| Skin | |||
| Keratinocyte cell lines | P2X2,3,5 and 7 | P2Y1,2,4,6 and 11 | |
| Pancreas | |||
| Acinar cells | P2X12,3,4,6 and 7 | P2Y1,2,4,11,12,13 and 14 | A1, A2A, A2B |
| Duct cells | P2X1,2,4,5,6 and 7 | P2Y1,2,4,6,11,12,13 and 14 | A1, A2A, A2B, A3 |
| Xenopus oocytes | P2X4 | P2Y2-like | Atypical A1 |
| Stem cells | |||
| Mesenchymal stem cells | P2X4,5,6 and 7 | P2Y1,2,4,11,13 and 14 | A1, A2A, A2B |
| Gut | |||
| Epithelial cell lines | P2X7 | P2Y2, P2Y6 | A2A, A2B |
| Salivary glands | |||
| Submandibular gland | P2X1-7 | P2Y1, P2Y2 | |
| Kidney | |||
| Collecting duct epithelial cells | P2X4, P2X5, P2X6 | P2Y1,2,4 and 6 | A1, A2A, A2B, A3 |
| A6 distal nephron epithelial cells | P2X4 | P2Y1, P2Y2 | A1, A2 |
| MDCK cells | P2X7 | P2Y1,2,6 and 11 | A1 |
| Epithelia from cysts of polycystic kidneys | P2X4, P2X5 | P2Y1, P2Y2, P2Y6 | |
| Blood cells | |||
| Erythrocytes | P2X1, P2X4, P2X7 | P2Y1, P2Y2 | A2B |
| Platelets | P2X1 | P2Y1, P2Y12, P2Y14 | A2A, A2B |
| Leukocytes | P2X4, P2X7 | P2Y2, P2Y6 | A1, A2A, A2B, A3 |