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Multiple miRNA biogenesis pathways. Five different pathways by which mature microRNA molecules are generated, including canonical pathway, mirtron pathway, simtron pathway, 5′ methyl-guanosine pathway, and miR-451 pathway. AGO Argonaute proteins 1–4, DGCR8 DiGeorge critical region 8, RISC RNA-induced silencing complex, XPO5 exportin 5
