Table 2.
Skin therapeutic applications of microRNAs
| Skin therapeutic application | microRNA | Target(s) | References |
|---|---|---|---|
| Psoriasis | miR-203 | SOCS3, p63 | Wang et al. [145] Huang et al. [103] Bracke et al. [102] Joyce et al. [49] Sonkoly et al. [146] Bostjancic et al. [147] |
| miR-146a | IL-17, IRAK1, TRAF6 | Srivastava et al. [99] Meisgen et al. [148] Sonkoly et al. [146] Bostjancic et al. [147] |
|
| miR-217 | GRHL2 | Zhu et al. [101] | |
| miR-99a miR-99b miR-100 |
IGF-1R | Joyce et al. [49] Lerman et al. [50] Sonkoly et al. [48] |
|
| miR-125b | FGFR2 | Xu et al. [68] | |
| miR-181b | TLR4 | Feng et al. [98] | |
| miR-31 | STK40 | Wang et al. [145] Xu et al. [100] |
|
| miR-197 | IL-17R, IL-22R | Sonkoly et al. [48] Lerman et al. [53] Elharrar et al. [52] |
|
| Atopic dermatitis | miR-146a | CCL5, IRAK1, TRAF6 | Urgard et al. [109] Rebane et al. [106] Sonkoly et al. [146] |
| miR-155 | CTLA-4 | Sonkoly et al. [108] | |
| UV-B damage | miR-141 | PTEN | Li et al. [86] |
| Moisturizing | miR-434-5p | HYAL | Chen et al. [142] |
| Pigmentation | miR-434-5p | TYR | Wu et al. [67] |
| miR-145 | SOX9, TYR, TRP1, MITF | Dynoodt et al. [65] | |
| miR-25 | MITF | Zhu et al. [69] | |
| miR-125b | TYR, DCT | Kim et al. [149] | |
| miR-155 | SOCS1, IFITM1, TRP1 | Sahmatova et al. [72] | |
| miR-211 | TGF-β receptor | Dai et al. [64] | |
| miR-330-5p | TYR | Rambow et al. [66] | |
| miR-137 | MITF | Bemis et al. [70] | |
| miR-182 | MITF, FOXO3 | Segura et al. [71] | |
| Acne | miR-143 | TLR2 | Xia et al. [95] |
| miR-105 | TLR2 | Benakanakere et al. [94] | |
| Skin aging | miR-29 | p53 | Li et al. [73] |
| miR-155 | c-Jun | Song et al. [84] |
CCL5 chemokine ligand 5, CTLA-4 cytotoxic T-lymphocyte-associated antigen 4, DCT dopachrome tautomerase, FGFR2 fibroblast growth factor receptor 2, FOXO3 Forkhead box protein O3, GRLH2 grainy head like transcription factor 2, HYAL hyaluronidase, IFITM1 interferon induced transmembrane protein 1, IGF-1R insulin-like growth factor-1 receptor, IL interleukin, IRAK1 interleukin-1 receptor associated kinase 1, miRNA microRNA, MITF microphthalmia-associated transcription factor, PTEN phosphatase and tensin homolog, SOCS suppressor of cytokine signaling, SOX9 Sry-related high mobility group protein 9, STK40 serine/threonine kinase 40, TGF transforming growth factor, TLR toll-like receptor, TRAF6 tumor necrosis factor receptor associated factor 6, TRP1 TYR-related protein 1, TYR tyrosinase, UV ultraviolet