Table 1.

Cell proliferation expressed by cell growth rate per hour (Lambda (h-1)) and p-values.

	LAMBDA (h-1) [CI95%]	p-value (Vs Control)	p-value (Vs 10 Gy)	p-value (Vs Cetuximab)
SQ20B
Control	0.0325 [0.0278–0.037]		—	—
Pertuzumab	0.041 [0.035–0.047]	0.021	—	—
Cetuximab	0.015 [0.013–0.017]	<0.001	—	—
Cetuximab + Pertuzumab	0.00746 [0.006–0.0085]	<0.001	—	<0.001
10 Gy	0.0122 [0.0097–0.147]	—	—	—
10 Gy + Pertuzumab	0.0137 [0.011–0.016]	—	0.42	—
10 Gy + Cetuximab	0.00275 [0.0019–0.0035]	—	<0.001	—
10 Gy + Cetuximab + Pertuzumab	0.000614 [0.0001–0.00012]	—	<0.001	<0.001
SQ20B-CSCs
Control	0.0351 [0.025–0.045]	—	—	—
Pertuzumab	0.0374 [0.025–0.05]	0.78	—	—
Cetuximab	0.0333 [0.024–0.043]	0.8	—	—
Cetuximab + Pertuzumab	0.0236 [0.017–0.031]	0.061	—	0.047
10 Gy	0.0157 [0.01–0.021]	—	—	—
10 Gy + Pertuzumab	0.0153 [0.01–0.021]	—	0.93	—
10 Gy + Cetuximab	0.014 [0.009–0.019]	—	0.64	—
10 Gy + Cetuximab + Pertuzumab	0.00939 [0.0059–0.013]	—	0.046	0.169
FaDu
Control	0.036 [0.31–0.40]	—	—	—
Pertuzumab	0.0347 [0.0302–0.0392]	0.75	—	—
Cetuximab	0.0239 [0.0208–0.027]	<0.001	—	—
Cetuximab + Pertuzumab	0.0165 [0.014–0.019]	<0.001	—	<0.001
10 Gy	0.0102 [0.0088–0.012]	—	—	—
10 Gy + Pertuzumab	0.00914 [0.0079–0.014]	—	0.31	—
10 Gy + Cetuximab	0.00715 [0.006–0.008]	—	<0.001	—
10 Gy + Cetuximab + Pertuzumab	0.00377 [0.0031–0.0045]	—	<0.001	<0.001

Leg. Lambda (h-1): cell growth rate per hour; CI95%: confidence interval; Vs: versus; Gy: Gray.