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. 2017 Sep 22;7:12139. doi: 10.1038/s41598-017-11639-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PAS-Seq library and bioinformatics workflow. (a) Schematic overview of PAS-Seq library preparation workflow. (b). PAS-Seq bioinformatics pipeline schematic. (c) Representative view of read alignment locations (top track) and called PAS peaks (bottom track) on the ADAM12 3′-UTR. Our algorithm is able to remove background noise, filter out internal priming sites and accurately identify true polyadenylation sites. (d) Distribution of PAS peaks among named gene classes and intergenic regions.