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. 2017 Sep 22;7:12139. doi: 10.1038/s41598-017-11639-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FLT1 alternative PAS isoform analysis. (a) Schematic of FLT1 gene and six previously identified mRNA isoforms arising from alternative polyadenylation. Thick boxes: protein coding exons; thin boxes: 3′-UTRs; lines: introns; arrows: sFlt1 and mFlt1 polyadenylation sites. Table shows all previous isoform names and new systematic names. (b) UCSC genome browser view showing PAS-Seq peak distribution on the FLT1 gene for a representative CTRL (top track), EO-PE (middle-track) or LO-PE (bottom track) patient. Arrows: sFlt1 and mFlt1 polyadenylation sites for isoforms in (a). (c) Bar graph showing mean expression (counts per million; CPM) across all libraries for all 16 detected mRNA isoforms at the FLT1 locus.